Uncomfortable side effects that typically tend not to involve clinical notice (report back to your doctor or well being treatment Skilled should they continue or are bothersome):
cyclophosphamide will improve the degree or impact of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unidentified.
Keep away from or substitute another drug for these medications when probable. Consider for loss of therapeutic outcome if medication should be coadministered. Alter dose As outlined by prescribing details if required.
Minor (one)modafinil will increase the level or effect of rabeprazole by impacting hepatic enzyme CYP2C19 metabolism. Minor/Significance Unidentified. Net effect on pantoprazole actions unfamiliar due to opposing consequences of CYP450 enzymes; keep track of
modafinil will increase the level or impact of citalopram by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Keep an eye on. Citalopram 20 mg/day is the maximum proposed dose for sufferers having CYP2C19 inhibitors because of the danger of QT prolongation.
Stay away from or substitute A different drug for these medications when attainable. Consider for loss of therapeutic outcome if medication should be coadministered. Regulate dose As outlined by prescribing info if wanted.
Tic Diseases, which include Tourette’s syndrome, which can be worsened by stimulants like modafinil.
Modafinil won't cure obstructive rest apnea or deal with its underlying causes. Observe your doctor's Recommendations about all of your other remedies for this problem.
Clopidogrel efficacy might be reduced by medication that inhibit CYP2C19. Inhibition of platelet aggregation by clopidogrel is solely resulting from an active metabolite. Clopidogrel is metabolized to this Energetic metabolite partially by CYP2C19. .
A 2020 critique claimed that modafinil includes a modest impact on memory updating, though the effect is modest and should not properly replicate the notion that it's practical as a cognitive enhancer, as There is certainly insufficient evidence to help such a assert.[264]
Signs of high blood pressure level like extremely undesirable headache or dizziness, passing out, or change in eyesight.
Modafinil reportedly assisted lessen the sleepiness induced by a genetic problem that triggers the progressive decline and weakening of muscles (
Stiripentol is usually a CYP3A4 inhibitor and inducer. Check CYP3A4 substrates coadministered with stiripentol for amplified or decreased consequences. CYP3A4 substrates could have to have dosage adjustment.
Medicines that have amount limitations associated with each prescription. This restriction commonly boundaries the amount on the drug which will be more info included.